Fig. 7. Estrogen is renoprotective after cardiac arrest/cardiopulmonary resuscitation (CA/CPR) in the presence of pharmacologic estrogen receptor (ER) blockade. Female C57BL/6 mice underwent ovariectomy and were treated with either 17β-estradiol (estradiol, n = 12) or 17β-estradiol and ICI 182,780 (estradiol-ICI, n = 8), a nonspecific ER antagonist before CA/CPR. Blood and tissue samples were collected 24 h after CA/CPR. There is no difference in functional or histopathologic injury between ER-free and ER-blockaded animals. (A  and B ) Blood urea nitrogen (BUN) and creatinine, respectively. (C ) Stereological assessment of volume of necrotic tubules as percent of total renal tissue volume. Data presented are mean ± SEM.

Fig. 7. Estrogen is renoprotective after cardiac arrest/cardiopulmonary resuscitation (CA/CPR) in the presence of pharmacologic estrogen receptor (ER) blockade. Female C57BL/6 mice underwent ovariectomy and were treated with either 17β-estradiol (estradiol, n = 12) or 17β-estradiol and ICI 182,780 (estradiol-ICI, n = 8), a nonspecific ER antagonist before CA/CPR. Blood and tissue samples were collected 24 h after CA/CPR. There is no difference in functional or histopathologic injury between ER-free and ER-blockaded animals. (A  and B ) Blood urea nitrogen (BUN) and creatinine, respectively. (C ) Stereological assessment of volume of necrotic tubules as percent of total renal tissue volume. Data presented are mean ± SEM.

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