Fig. 5. The effects of 14 mg/kg of carboetomidate (n = 7), 2 mg/kg of etomidate (n = 6), and dimethyl sulfoxide (DMSO) vehicle alone (n = 4) on mean blood pressure in rats. Hypnotics were given at doses equal to twice their respective ED50s for loss of righting reflex in DMSO vehicle. All rats received the same quantity of DMSO vehicle (350 μl/kg). Hypnotic in DMSO vehicle or DMSO vehicle alone was injected at time 0. Each data point represents the average (±SD) change in mean blood pressure during each 30-s epoch. *P < 0.05 versus DMSO vehicle alone.