Fig. 1. Perioperative changes in aggregation units in response to collagen (2 μg/ml). Acceleration of perioperative whole blood aggregation was significantly lower in the milrinone-treated group [Mil(+)] compared with the group not treated with milrinone [Mil(−)] at 2.5 and 8 h after the commencement of surgery. Data are shown as percent change from preoperative (0 h) values (mean ± SD, n = 17/group). Open bars = Mil(−) group; solid bars = Mil(+) group. * P < 0.01 compared with baseline (0 h) in each group. † P < 0.01 compared with Mil(−) at each time point. § P < 0.05 compared with Mil(−) at each time point .