Fig. 5. Effects of isoflurane on contractile response to norepinephrine (NE) in endothelium-denuded (−E) strips from control (nondiabetic) or diabetic rats. Examples in control (A ) and diabetic (B ) rats. Comparisons of maximal (C ) and submaximal (D ) contractile responses to NE during exposure to isoflurane (i.e ., 5 min after application of isoflurane; left in each panel) and 5 min after washout of isoflurane (right in each panel) between control (open columns ) and diabetic (closed columns ) rats. EC50= half-maximal effective concentration, n = 10. *P < 0.05 versus control (100%) within each group.