Fig. 2. Effects of sevoflurane on contractile response to norepinephrine (NE) in endothelium-intact (+E) strips from control (nondiabetic) or diabetic rats. (A , B ) Examples in control (A ) and diabetic (B ) rats. (C , D ) Comparisons of maximal (C ) and submaximal (D ) contractile responses to NE during exposure to sevoflurane (i.e ., 5 min after application of sevoflurane; left in each panel) and 5 min after washout of sevoflurane (right in each panel) between control (open columns ) and diabetic (closed columns ) rats. EC50= half-maximal effective concentration, n = 12. *P < 0.05 versus control (100%) within each group. # P < 0.05 versus control rats at each concentration.