Fig. 4.
Gene expression of interleukin-6 (IL-6), club cell secretory protein-16 (CC-16), and vascular cell adhesion molecule-1 (VCAM-1) in lung tissue. Boxplots represent the median and interquartile range of 7 animals per group. Comparisons were done by Kruskal-Wallis test followed by Dunn’s multiple comparisons test (P < 0.05). IL-6: Control group did not differ from abrupt increase of RR for 1 h (P = 0.569), shorter (P = 0.999) and longer (P = 0.999) RR adaptation groups. Abrupt increase of RR for 1 h did not differ from shorter (P = 0.999), longer (P = 0.641) RR adaptation groups and abrupt increase of RR for 2 h (P = 0.999). Shorter RR adaptation did not differ from longer RR adaptation (P = 0.999) and abrupt increase of RR for 2 h (P = 0.999). CC-16: Control group did not differ from shorter and longer (P = 0.153 for both) RR adaptation groups. Abrupt increase of RR for 1 h did not differ from shorter and longer RR adaptation groups and abrupt increase of RR for 2 h (P = 0.999 for all). Shorter and longer RR adaptation did not differ from abrupt increase of RR for 2 h (P = 0.907 for both). VCAM-1: Control group did not differ from shorter and longer (P = 0.999 for both) RR adaptation groups. Abrupt increase of RR for 1 h did not differ from shorter (P = 0.203), longer (P = 0.999) RR adaptation groups and abrupt increase of RR for 2 h (P = 0.999). Shorter RR adaptation did not differ from longer RR adaptation (P = 0.999). Longer RR adaptation group did not differ from abrupt increase of RR for 2 h (P = 0.118). RR, respiratory rate.