Fig. 3.
All observations of the Patient State Index (PSI) obtained during steady-state observation phases plotted versus measured plasma concentrations of dexmedetomidine (DMED) and remifentanil (REMI). Lines are locally estimated scatterplot smoothers. Remifentanil concentrations are plotted in the interaction phases, with 0 representing a dexmedetomidine background concentration of 2 ng/ml with 0 ng/ml remifentanil.