American Society of Anesthesiologists

Fig. 5.

Log likelihood profiles for C50S-ketamine (A), C100S-norketamine (B), and t1/2ke0 (C) parameters. The red line shows the final parameter 95% CI as determined by Perl speaks NONMEM, “llp” utility. C50S-ketamine, estimated S-ketamine effect-site concentration needed to increase the pain pressure threshold by 100%; C100S-norketamine, effect-site S-norketamine concentration causing a 100% increase in C50S-ketamine; t1/2ke0, S-ketamine and S-norketamine blood-effect site equilibration half-life.

Log likelihood profiles for C₅₀S-ketamine (A), C₁₀₀S-norketamine (B), and t_1/2k_e0 (C) parameters. The red line shows the final parameter 95% CI as determined by Perl speaks NONMEM, “llp” utility. C₅₀S-ketamine, estimated S-ketamine effect-site concentration needed to increase the pain pressure threshold by 100%; C₁₀₀S-norketamine, effect-site S-norketamine concentration causing a 100% increase in C₅₀S-ketamine; t_1/2k_e0, S-ketamine and S-norketamine blood-effect site equilibration half-life.

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