Fig. 6. EE attenuates the sevoflurane-induced cognitive impairment in mice. (A ) The flow diagram and photographs of EE and SE. (B ) Two-way ANOVA with repeated measurement analysis shows that there is a statistically significant interaction of time and group based on escape latency in MWM between mice following sevoflurane anesthesia plus SE and sevoflurane anesthesia plus EE (control, n = 11; sevoflurane, n = 15). (C ) The Mann–Whitney U  test shows that the platform crossing times of mice swimming in the MWM following the sevoflurane anesthesia plus EE is not significantly different from that of mice following the sevoflurane anesthesia plus SE (control, n = 11; sevoflurane, n = 15). (D ) Two-way ANOVA with repeated measurement analysis shows that there is no statistically significant interaction of time and group based on escape latency of MWM between the control condition plus SE and the control condition plus EE (control, n = 11; sevoflurane, n = 11). (E ) The Mann–Whitney U  test shows that there is no significant difference in platform crossing times of mice swimming in the MWM between the control condition plus SE and the control condition plus EE (control, n = 11; sevoflurane, n = 11). EE, enriched environment; MWM = Morris water maze; SE = standard environment.