Fig. 5. The effect of posttreatment (30 min after the surgery: A , C , and E ; 24 h after the surgery: B , D , and F ) with gabexate, ENMD-1068 or cromoglycate on mechanical hyperalgesia after plantar surgery in mice. The effect of post-administration of gabexate (1 nmol/paw, intraplantar [i.pl.]) (A or B ), ENMD-1068 (100 nmol/paw, i.pl.) (C or D ) or cromoglycate (200 µg/paw, i.pl.) (E or F ) on mechanical hyperalgesia after plantar surgery in mice. B1 indicates the measurement of the baseline mechanical threshold of the animals before plantar surgery, and B2 indicates the measurement of the baseline mechanical threshold of the animals after plantar surgery and before treatments. The vertical bars represent the means + SEM for (A , n = 7 to phosphate buffered saline [PBS] and n = 8 to gabexate groups; B , C , D , E , F , n = 6 to all groups).