Fig. 3. The effect of pretreatment with gabexate, ENMD-1068, cromoglycate, or ketotifen on spontaneous nociception after plantar surgery in mice. The effect of the preadministration of gabexate (1 nmol/paw, intraplantar [i.pl.]) (A ), ENMD-1068 (100 nmol/paw, i.pl.) (B ), cromoglycate (200 µg/paw, i.pl.) (C ) or ketotifen (10 mg × kg−1× day−1, per os [p.o.]) (D ) on the sum of spontaneous nociception scores from 0.5 to 1 h after plantar surgery in mice. The vertical bars represent the medians and interquartile ranges for (A , n=6 to phosphate buffered saline [PBS] and n = 5 to gabexate groups; B , n = 10 to both groups; C , n = 7 to PBS and n = 5 to cromoglycate groups; D , n = 6 to both groups). *P < 0.05, **P < 0.01 when compared to the PBS-treated group; Mann-Whitney U test.