Fig. 4. Glycine dependence of xenon (80%) inhibition of wild-type and GluN1mutant receptors. (A ) Xenon inhibition of wild-type GluN1/2A receptors increases as glycine concentration is reduced. For the GluN1 F758 mutants, glycine dependence of inhibition is abolished. (B ) GluN1(F758A)/2A receptors, (C ) GluN1(F758L)/2A, and (D ) GluN1(F758W)/2A. The % of control represents the ratio of the current in the presence of anesthetic to that in the absence of anesthetic at each glycine concentration. The bars are mean values from an average of eight cells at each glycine concentration; the error bars are standard errors. *P < 0.025 is significantly different from inhibition at 100 μM glycine.