Fig. 2. Concurrent noxious stimulation attenuates ketamine-induced increases in cleaved caspase-3 (Cl-Csp3). Immunohistochemistry with antibody to Cl-Csp3 on S1 cortical sections from postnatal day 7 rat pups in groups (A ) control, (B ) CFA, (C ) ketamine + CFA and (D ) ketamine (scale bar = 10 μm). (E ) Quantitation of Cl-Csp3-immunoreactive cells in the ACC, S1, and S2 regions of the postnatal day 7 brain. ***P < 0.01 compared with saline. Values are means ± SE (n = 6). CFA = complete Freund's adjuvant; KET = ketamine.