![Fig. 4. The effect of verapamil on levobupivacaine (LBV) concentration-response curve in the endothelium-denuded aorta. Data are shown as mean ± SD and are expressed as a percentage of the maximal contraction induced by isotonic 60 mM KCl (100% = 3.61 ± 0.71 g [n = 6], 100 = 3.12 ± 0.49 g [n = 6], and 100% = 3.16 ± 0.39 g [n = 6] for endothelium-denuded aorta with no drug, 10−7M verapamil, and 5 × 10−7M verapamil, respectively). N indicates the number of rats from which descending thoracic aortic rings were derived. Verapamil (10−7M): *P = 0.0027 versus no drug at 10−5M LBV; ‡P = 0.0108 versus no drug at 3 × 10−4M LBV. †P < 0.001 versus no drug.](https://asa2.silverchair-cdn.com/asa2/content_public/journal/anesthesiology/114/2/10.1097_aln.0b013e3182054d22/4/17ff4.png?Expires=1716612057&Signature=2m-vdVZGVmdYo6UEk1bZ-p~XLK1UUs3m9Ef7KdQvi2TGfjUlo9YtvuGgLamuTF9-Dy8XRZQbEY6ykFZ6qj457jB6KGUJFFosQ6jA~XIBSCOhPxrYMk4DqX~rLJSMiJ5QHVBwubZdsE7uiPsgmijP7OyMMLRUys4XR04HCliJIYsSjeZuPBeyeGWPaYffPQ0zcfTGUP8SfCBADPdt3NokjG6jEYVmTuP~X9X-jyI0COzSNmnhGP3Z7cwnuhpdaj7Y3LiSEFU6KKmWshx3GpQXJP1fTSRakixfgfV0G5gOemiE-kyzAu~rjxkd8SzN5b~iSou2YRstYux9DQVEx7-wrA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Fig. 4. The effect of verapamil on levobupivacaine (LBV) concentration-response curve in the endothelium-denuded aorta. Data are shown as mean ± SD and are expressed as a percentage of the maximal contraction induced by isotonic 60 mM KCl (100% = 3.61 ± 0.71 g [n = 6], 100 = 3.12 ± 0.49 g [n = 6], and 100% = 3.16 ± 0.39 g [n = 6] for endothelium-denuded aorta with no drug, 10−7M verapamil, and 5 × 10−7M verapamil, respectively). N indicates the number of rats from which descending thoracic aortic rings were derived. Verapamil (10−7M): *P = 0.0027 versus no drug at 10−5M LBV; ‡P = 0.0108 versus no drug at 3 × 10−4M LBV. †P < 0.001 versus no drug.
