Fig. 1. Bupivacaine (Bup) inhibits the response to exogenous N -methyl-d-aspartate (NMDA). (A , B , and D ) Representative traces of NMDA-induced current, recorded at −40 mV before, during, and after bupivacaine application. Bupivacaine (0.5 mm, 2 mm) reversibly inhibited NMDA-induced currents. (C ) The relative amplitudes were 75 ± 8% of the control level in the presence of 0.5 mm bupivacaine and 53 ± 18% in the presence of 2 mm bupivacaine. *P < 0.01.

Fig. 1. Bupivacaine (Bup) inhibits the response to exogenous N -methyl-d-aspartate (NMDA). (A , B , and D ) Representative traces of NMDA-induced current, recorded at −40 mV before, during, and after bupivacaine application. Bupivacaine (0.5 mm, 2 mm) reversibly inhibited NMDA-induced currents. (C ) The relative amplitudes were 75 ± 8% of the control level in the presence of 0.5 mm bupivacaine and 53 ± 18% in the presence of 2 mm bupivacaine. *P < 0.01.

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