Fig. 1. Strychnine (▴0.75 mg/kg, intraperitoneal injection) and GABAzine (•5 mg/kg, subcutaneous injection) decrease the percentage of rats exhibiting loss of righting reflex (Percent LORR) induced by propofol (UNHANDLED_ENTITY, intraperitoneal, [  A ]) but not by ketamine (UNHANDLED_ENTITY, intraperitoneal, [  B ]). Minimum cohort size is six. The solid lines are the fit to the data, obtained with the logistic equation described in the method section. The EC⁵⁰(± SEM) and Hill coefficient (± SEM) values are 69.0 ± 0.8 mg/kg and 8.2 ± 0.6 for propofol alone, 96.0 ± 2.3 mg/kg and 4.6 ± 1.2 for propofol + strychnine, 104.5 ± 5.1 mg/kg and 3.8 ± 0.76 for propofol + GABAzine, 33.3 ± 0.5 mg/kg and 13.9 ± 4.3 for ketamine alone, and 33.2 ± 10. 4 mg/kg and 12.9 ± 74.9 for ketamine + strychnine, respectively.