Fig. 7. Effects of propofol medium chain triglyceride/long chain triglyceride (MCT/LCT) on cerebral blood flow (CBF) in Wistar-Kyoto rats (WKYs) and stroke-prone spontaneously hypertensive rats (SHRSPs). Typical tracing of CBF in WKYs ( A ) and SHRSPs ( B ). After CBF had stabilized at a baseline, propofol MCT/LCT (20 mg/kg) was administered by tail vein injection. CBF was continuously monitored for a period of 10 min, the same time course as the L-band electron spin resonance studies. The horizontal arrows on each trace correspond to the time from the start and end of L-band electron spin resonance measurement. ( C ) Each column represents baseline CBF before propofol MCT/LCT administration ( closed columns ; control), minimum CBF within a few seconds of propofol administration ( open columns ; propofol MCT/LCT), and CBF 10 min after propofol MCT/LCT administration ( gray columns ; recovery) in WKYs and SHRSPs. The results are expressed as mean ± SD of WKYs (n = 4) or SHRSPs (n = 4). * Significance ( P < 0.05) from the corresponding control values of WKYs and SHRSPs.