Fig. 2. Cold and mechanical hyperalgesia. In glabrous ( A ) and hairy ( B ) skin, cast immobilization induced cold pain hyperalgesia at cast removal (CR) and 3 days after cast removal (3 d). For all measures, no differences were seen 28 days after cast removal (28 d). Positive values indicate cold hyperalgesia. Pain thresholds at skin fold testing ( C ) of the immobilized hand were reduced at CR, 3 days, and 28 days after cast removal. The circles and error bars represent arithmetic means and 95% confidence intervals, respectively. The difference (diff.) is left − right hand. Closed circles : immobilized group (n = 30). Open circles : control group (n = 15). * Statistically significant inhibition. BL = baseline.