Fig. 5. Phospholamban content (  A ) and phosphorylation at serine 16 (  B ) and threonine 17 (  C ) after administration of desflurane, metoprolol, or KN-93 alone or in combination with desflurane. Results are presented as representative original immunoblottings and average densitometric results of immunoblotting as percentage of control. Values are mean ±SEM. n = 7 per group. CON = control; DES = 1.0 minimum alveolar concentration (MAC) desflurane; DES + KN-93 = desflurane + KN-93; DES + METO = 1.0 MAC desflurane + 2.5 mg/kg metoprolol; KN-93 = 300 μg/kg KN-93; METO = 2.5 mg/kg metoprolol; PLB = phospholamban. * Significantly (  P < 0.05) different from CON. 

Fig. 5. Phospholamban content (  A ) and phosphorylation at serine 16 (  B ) and threonine 17 (  C ) after administration of desflurane, metoprolol, or KN-93 alone or in combination with desflurane. Results are presented as representative original immunoblottings and average densitometric results of immunoblotting as percentage of control. Values are mean ±SEM. n = 7 per group. CON = control; DES = 1.0 minimum alveolar concentration (MAC) desflurane; DES + KN-93 = desflurane + KN-93; DES + METO = 1.0 MAC desflurane + 2.5 mg/kg metoprolol; KN-93 = 300 μg/kg KN-93; METO = 2.5 mg/kg metoprolol; PLB = phospholamban. * Significantly (  P < 0.05) different from CON. 

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