Fig. 4. Calcium/calmodulin-dependent protein kinase II (CaMK II) content after administration of desflurane, metoprolol, or KN-93 alone or in combination with desflurane. Results are presented as representative original immunoblottings and average densitometric results of immunoblotting as percentage of control. Values are mean ± SEM. CON = control; DES = 1.0 minimum alveolar concentration (MAC) desflurane; DES + KN-93 = desflurane + KN-93; DES + METO = 1.0 MAC desflurane + 2.5 mg/kg metoprolol; KN-93 = 300 μg/kg KN-93; METO = 2.5 mg/kg metoprolol. n = 7 per group.