Fig. 2. Effects of isoflurane (ISO) on KCl-induced increases in force and R340/380in either the absence or presence of ryanodine. (A ) Examples of the effects of isoflurane on the KCl response. The KCl responses before application of isoflurane (precontrol), 5 min after application of isoflurane, and 5 min after washout of isoflurane (postcontrol) were shown. (B ) Analyzed data (left , in the absence of ryanodine; right , in the presence of ryanodine) (n = 5). **P < 0.01 versus control; NS = not significantly different from control.