Fig. 5. Time course of coronary flow (CF) for each of the five groups. CF increased slightly during the 200-min time course in the nonischemia time control (CON) group. CF reversibly increased during sevoflurane exposure. CF was not altered by 5-hydroxydecanoate (5-HD) before, during, and after sevoflurane exposure. 5-HD alone did not effect CF. All ischemia groups exhibited a similar postischemic flow response on early reperfusion. During later reperfusion, coronary flow recovered better in the anesthetic preconditioning (APC) group than in other ischemia groups but did not reach CON values by the end of the experiment. See figure 2for statistical symbols.