Fig. 5. (A ) Lidocaine, when incubated for 60 min before human polymorphonuclear neutrophil (hPMN) activation with phorbol myristate acetate (PMA), does not affect superoxide anion production (after 30 min) significantly. (B ) Preincubation (90 min) of hPMNs with pertussis toxin (PTX; 0.3 μg/ml) inhibits superoxide anion production only partially, whereas combined pretreatment with lidocaine (10−4m) and PTX (0.3 μg/ml, gray bar) reduces O2− production to 31.4 ± 7.9% of control response. PAF = platelet-activating factor; fMLP =N -formylmethionine- leucyl-phenylalanine.

Fig. 5. (A ) Lidocaine, when incubated for 60 min before human polymorphonuclear neutrophil (hPMN) activation with phorbol myristate acetate (PMA), does not affect superoxide anion production (after 30 min) significantly. (B ) Preincubation (90 min) of hPMNs with pertussis toxin (PTX; 0.3 μg/ml) inhibits superoxide anion production only partially, whereas combined pretreatment with lidocaine (10−4m) and PTX (0.3 μg/ml, gray bar) reduces O2− production to 31.4 ± 7.9% of control response. PAF = platelet-activating factor; fMLP =N -formylmethionine- leucyl-phenylalanine.

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