Figure 5. Pseudosteady-state plasma thiopental concentrations versus chance of modeled probability to respond to various stimuli. Results are pooled from 30 rats for all responses except for movement response to intubation (n = 24 rats). The figure shows the separation of modeled response curves for nine different types of stimulus. The 95% confidence intervals for Cp50values are shown. Calculations are based on logistic regression analysis. Responses to unprovoked righting reflex (1), to provoked righting reflex (2), to noise (3), as extremity movement to tail clamp (4) or tail pressure (5), as abdominal contraction to tail clamp (6) or tail pressure (7), and to corneal reflex (8) and intubation (9).

Figure 5. Pseudosteady-state plasma thiopental concentrations versus chance of modeled probability to respond to various stimuli. Results are pooled from 30 rats for all responses except for movement response to intubation (n = 24 rats). The figure shows the separation of modeled response curves for nine different types of stimulus. The 95% confidence intervals for Cp50values are shown. Calculations are based on logistic regression analysis. Responses to unprovoked righting reflex (1), to provoked righting reflex (2), to noise (3), as extremity movement to tail clamp (4) or tail pressure (5), as abdominal contraction to tail clamp (6) or tail pressure (7), and to corneal reflex (8) and intubation (9).

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