Figure 1. Representative recordings of the effects of isoflurane (A; 5.0 vol%) and sevoflurane (B; 5.0 vol%) on peak amplitude of Calcium2+ current (ICa). The currents were recorded in response to a 200-ms depolarizing pulse to +20 mV from a holding potential of -40 mV. C = control; I = isoflurane; R = recovery; S = sevoflurane. The effects of isoflurane (C; 5.0 vol%; n = 7) and sevoflurane (D; 5.0 vol%; n = 10) on the current-voltage relationships were obtained by plotting the peak normalized ICaas a function of the membrane potential (mV). Open symbols = control; closed circles = isoflurane; closed squares = sevoflurane. Symbols represent mean+/-SEM. *P < 0.05 for difference from control.