Figure 1. The time course of antagonism of profound mivacurium- induced neuromuscular blockade with human plasma cholinesterase in the case described. The total elapsed time from the first dose of plasma cholinesterase until a train-of-four ratio (TOF) of 0.75 reached was 85.3 min. Miva - mivacurium; Neo - neostigmine; PCHE - human plasma cholinesterase (the corresponding doses are equivalent to plasma cholinesterase activity of fresh normal human plasma); T1 first twitch of the TOF stimulation (percent of control); Total = total cumulative doses of PCHE.