Fig. 10. Example of chronopharmacokinetic study. Plasma concentrations of indomethacin (ng/ml) were measured in volunteers after 75 mg oral administration at 08:00 (open squares ), 12:00 (solid circles ), and 20:00 h (open circles ). From Bruguerolle B: A propos de la chronopharmacologie (in French). Act Pharmacol 2001; 398:17–21. Used with permission.