Fig. 4.
Clearance predictions for linear weight scaled adult and children models versus an allometric model. The black lines are the allometric model; straight lines are weight linear models developed for children (red) and adults (blue). Dotted lines indicate extrapolated predictions. Gray shaded area indicates the weight range of the children and adult populations. Within the children or adult populations, the allometric model is closely approximated by the linear model. If an error is made and the incorrect model is chosen, the predicted clearance will be 57% of intended in children and 176% in adults and will likely result in nonoptimal initial dosing. This error cannot be made with the allometric model. CL, drug clearance (relative to 70-kg adult); WGT, body weight (in kg).