Fig. 7.
Acute safety profile of loperamide-oxymorphindole. (A) Arterial blood oxygenation was continuously monitored using a STARR MouseOx Plus (Starr Life Sciences Corp., USA) to assess respiratory effects. After acclimation and baseline readings, animals were administered either saline, or increasing doses of fentanyl, loperamide, oxymorphindole, or loperamide–oxymorphindole, and oxygen saturation measured by pulse oximetry readings were recorded. Data were analyzed by ordinary one-way ANOVA with Bonferroni test for multiple comparisons. ****P < 0.0001 versus baseline. (B) Constipation was assessed by counting fecal boli produced for 1 h after drug or saline administration. Data were analyzed by ordinary one-way ANOVA with Bonferroni test for multiple comparisons. *P < 0.05, **P < 0.01, ****P < 0.0001 versus vehicle.

Acute safety profile of loperamide-oxymorphindole. (A) Arterial blood oxygenation was continuously monitored using a STARR MouseOx Plus (Starr Life Sciences Corp., USA) to assess respiratory effects. After acclimation and baseline readings, animals were administered either saline, or increasing doses of fentanyl, loperamide, oxymorphindole, or loperamide–oxymorphindole, and oxygen saturation measured by pulse oximetry readings were recorded. Data were analyzed by ordinary one-way ANOVA with Bonferroni test for multiple comparisons. ****P < 0.0001 versus baseline. (B) Constipation was assessed by counting fecal boli produced for 1 h after drug or saline administration. Data were analyzed by ordinary one-way ANOVA with Bonferroni test for multiple comparisons. *P < 0.05, **P < 0.01, ****P < 0.0001 versus vehicle.

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