Fig. 4.
Thrombin generation: Endogenous thrombin potential (A, study part one: control, prothrombin complex concentrate [PCC] 12.5, PCC 25, and 50 U/kg PCC, and B, study part two: control, 12.5 U/kg PCC, 12.5 U/kg PCC plus tranexamic acid, 12.5 U/kg PCC plus tranexamic acid and fibrinogen concentrate). Peak height (C: study part one, and D: study part two). The data are presented as means ± SD, considering study group × observation time interaction. Initially, n = 8/group; in the control group, n = 7 at 120 min, n = 5 at 180 min, and n = 1 at 240 min after trauma. In the 12.5 U/kg PCC plus tranexamic acid group, n = 7 at 120 min and n = 5 at 240 min after trauma. *P < 0.05 versus all other groups; †P < 0.05 versus control; ¶P < 0.05 versus 12.5 U/kg PCC; XP < 0.05 versus control and 12.5 U/kg PCC; #P < 0.05 versus 50 U/kg PCC.