Fig. 1.
Illustration of the patient selection and matching process. In both groups, extracellular vesicles were isolated from pre- and postoperative sera. Vesicular microRNA profiles were subsequently assessed by next generation sequencing (NGS). After stringent quality filtering, eight (propofol) and nine (sevoflurane) patients were included for in silico analyses and validation by real-time quantitative polymerase chain reaction (RT-qPCR).