Adjusted risk ratios for all time-weighted average area under the curve thresholds for ETco₂ and MAP. All reference categories are shown in the plot with an effect estimate of 1.00. Bonferroni correction was used to correct for the number of categories within an independent variable and CIs are reported accordingly. For example: when four categories were made within an independent variable, a P value of < 0.0125 was considered as statistical significant after a Bonferroni correction (0.05/4) with a corresponding CI of 98.8%. The models were adjusted for age, gender, history of myocardial infarction, cerebrovascular disease, diabetes mellitus, hypertension, vascular disorders (central and peripheral), (history of) smoking, World Federation of Neurologic Surgeons Grading System Score on admission, intervention modality (clipping or coiling), day of intervention, number of times receiving general anesthesia before and after the intervention, cerebral spinal fluid drainage, postoperative neurologic decline, rebleed, edema, cerebral ischemia, hydrocephalus, anemia, extracranial complications, preoperative MAP, amount of ephedrine, phenylephrine and noradrenaline per hour, preoperative oxygenation level, and year of procedure. Additionally, the results for the ETco₂ thresholds were adjusted for the mean MAP per case, whereas the results for the MAP thresholds were adjusted for the mean ETco₂ per case. ETco₂, end-tidal carbon dioxide; GOS, Glasgow Outcome scale (dichotomized into a good outcome [GOS score 4 to 5] and a poor outcome [GOS score 1 to 3]); MAP, mean arterial blood pressure; Reference, reference category.