Fig. 2.
Change from baseline and subsequent mean values for cold pressor testing, which was performed 15 min after each injection (4-, 4-, 8-, and 16-mg individual doses given 90 min apart, corresponding to cumulative doses of 4, 8, 16, and 32 mg, respectively), as well as 90 and 180 min after final drug administration. Repeated-measures ANOVA with Bonferroni correction was used to examine pairwise comparisons at each time point. Bars represent sample means, and error bars represent standard deviations. For hydromorphone versus placebo, *P < 0.05. For buprenorphine versus placebo. #P < 0.05.