Fig. 3.
The depression, recovery, and subsequent up-regulation of the Ca2+ transient (ΔCai) after lipopolysaccharide (LPS) administration. (A) Typical experimental recordings of Cai transients in isolated, externally paced cardiomyocytes at baseline and at different times after LPS administration (as shown). (B–E) Average ΔCai (B), Ca2+ rise velocity (ΔCai/dt; C), Cai transient time to peak (D), time constant of Ca2+ decay (τCa; E), and diastolic Cai levels (F) in cells isolated from mice at baseline and at different times after LPS administration. Data are shown as mean ± SD. N = 42 cells from seven mice at baseline (42/7) at baseline, 45/5 for 12 h, 18/2 for day 1, 38/4 for day 3, 19/2 for day 4, 17/3 for day 6, and 16/2 for day 12. BL = baseline; r.u. = ratiometric units. *P < 0.05 versus baseline.