Fig. 3.
Concentration dependencies of anesthetic activation of ryanodine receptor 2 (RyR2) open probability (A), opening rate, ko (B), and mean open time, To (C). Experimental conditions and composition of vehicle solution are given in figure 2. (B and C) Sevoflurane data are omitted for clarity. Data show the mean ± SD. Curves show fits of Hill equation to the Po data using the criterion of least-squares. Fit parameters and numbers of channels are given in table 1.