Fig. 3.
The effects of varenicline and ABT 594 on the baseline breathing. Population data (median and interquartile ranges for A; mean and SD for B) showing the effects of administration of varenicline (1 mg/kg neck subcutaneous injection, intravenous injection) or ABT 594 (30 µg/kg, subcutaneous; 10, or 20 µg/kg, intravenous) or saline on respiratory parameters (A: respiratory frequency, fR; B: minute ventilation, ; relative to control before drug administration). *P < 0.05, statistically significant difference compared with saline group. Kruskal–Wallis one-way ANOVA on ranks (Tukey method) for A; one-way ANOVA for B. n = 5 animals for each group.