Morphine administration in the anterior cingulate cortex has some inhibitory effects on spinal (deep dorsal horn) wide dynamic range neuronal responses to suprathreshold stimuli with only marginal differentiating effects before and after neuropathy. The response profiles of deep dorsal horn neurons to a range of innocuous and noxious natural and electrical stimuli before and after microinjection of morphine (10 µg/0.5 µl) into the anterior cingulate cortex of control (naïve/sham-operated; n = 7 rats and 7 single unit cell recordings) or spinal nerve–ligated rats (n = 9 rats and 9 single unit cell recordings) are shown. All data are presented as means ± 95% CI. In both animal groups, microinjection of morphine into the anterior cingulate cortex reduced the excitability of spinal neurons to a subset of peripherally applied mechanical stimuli (A and B), as well as to peripherally applied thermal stimuli (C and D). Input and brush-evoked spinal neuronal responses were statistically significantly reduced in neuropathic but not control animals (E and F). Statistically significant differences from baseline responses are shown with asterisks: *P < 0.05, **P < 0.01, ***P < 0.001.