Fig. 1.
Pharmacokinetic and pharmacodynamic data after intravenous injection with oliceridine and morphine in healthy volunteers. (A) Plasma oliceridine and morphine concentrations. (B) Hand withdrawal latencies. (C) Ventilatory responses to hypercapnia. Three oliceridine doses were injected, 1.5 mg (gray symbols), 3 mg (blue symbols), and 4.5 mg (orange symbols), and one morphine dose of 10 mg (red symbols). Data are mean ± 95% CI.