American Society of Anesthesiologists

Fig. 3.

Removal of extracellular Ca2+ prevents the 1-oleoyl-2-acetyl-sn-glycerol-induced increase in intracellular Ca2+ concentration. Removal of extracellular Ca2+ lowered the intracellular Ca2+ concentration and provoked the inhibition of 1-oleoyl-2-acetyl-sn-glycerol (100 μM)–induced elevation of intracellular Ca2+ concentration in flexor digitorum brevis fibers isolated from Wild type, RYR1-p.G2435R heterozygous, and RYR1-p.G2435R homozygous mice. On the horizontal axis are indicated the experimental conditions used. For intracellular Ca2+ concentration measurements: Nmice= 3 per experimental condition, Ncell= 10 to 14 per genotype. Values are expressed as means ± SD for each condition. One-way ANOVA with Tukey post hoc test. *P ≤ 0.05.

Removal of extracellular Ca²⁺ prevents the 1-oleoyl-2-acetyl-sn-glycerol-induced increase in intracellular Ca²⁺ concentration. Removal of extracellular Ca²⁺ lowered the intracellular Ca²⁺ concentration and provoked the inhibition of 1-oleoyl-2-acetyl-sn-glycerol (100 μM)–induced elevation of intracellular Ca²⁺ concentration in flexor digitorum brevis fibers isolated from Wild type, RYR1-p.G2435R heterozygous, and RYR1-p.G2435R homozygous mice. On the horizontal axis are indicated the experimental conditions used. For intracellular Ca²⁺ concentration measurements: N_mice= 3 per experimental condition, N_cell= 10 to 14 per genotype. Values are expressed as means ± SD for each condition. One-way ANOVA with Tukey post hoc test. *P ≤ 0.05.

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