Fig. 10.
Simulated concentration time profiles with the three-compartment meta-analytical model (green line) and the arterial (red line) and venous (blue line) population models derived from the raw data sets after a 40-min infusion of 0.5 mg/kg esketamine or racemic ketamine in a 70-kg person. Three scenarios were simulated: S-ketamine concentrations after esketamine administration (A), S-ketamine after racemic ketamine (B), and R-ketamine after racemic ketamine (C).