Fig. 1.
Infographic summarizing the missing pieces to define the optimal tranexamic acid dosing regimen in cardiac surgery. (1) The true incidence of seizures and the minimal cerebrospinal fluid concentration needed to avoid the risk of seizure and its associated plasma concentration. (2) The range of plasma concentrations required to inhibit fibrinolytic activation. (3) Assays that would better able to estimate the effect of tranexamic acid on fibrinolytic activation in vivo. Figure created with BioRender.com.