Fig. 4.
Asynchronous spike firing between pyramidal neurons without common inputs from a fast-spiking neuron. (A) Schematic of triple whole cell patch clamp recording from two pyramidal neurons, only one of which receives inhibitory inputs from a fast-spiking neuron. (B) Pyramidal neuron spike recordings before and during the 10 μM propofol application. Pyramidal neuron 1 but not pyramidal neuron 2 received inhibitory inputs from the fast-spiking neuron. Ten consecutive traces are shown. Note that only pyramidal neuron 1 showed spike firing with a relatively rigid latency in epochs 1 to 4 during propofol application. (C) Plots of spike timing of pyramidal neuron 1 and pyramidal neuron 2 before and during propofol application from epochs 0 to 7 obtained from 16 pyramidal neuron pairs. No obvious plot alignment was observed in either the control or propofol conditions. (D) The average distance from the line of identity was not significantly changed by propofol. Lines and dotted lines indicate the SD of control and propofol application, respectively.