Fig. 5.
Effect of bupivacaine on the temporal response of dorsal horn and intermediolateral neurons to myocardial ischemia. (A) Average neural activity of the dorsal horn (n = 791; with SEM of neural firing at each timepoint shown in gray) and (B) intermediolateral (n = 33) neural activity during 5-min left anterior descending (LAD) coronary occlusion without bupivacaine administration. The shaded yellow area highlights the periods during LAD occlusion in which the dorsal horn and intermediolateral neurons demonstrated correlated activity. (C) Average dorsal horn (n = 791) and (D) intermediolateral (n = 33) neuronal activity during LAD occlusion with bupivacaine administration. Error bars show SD.