Fig. 5.
Time course of neutrophil gelatinase-associated lipocalin (NGAL) in plasma (A), and acute kidney injury (AKI) score (B). Values of NGAL are given as box-plots (median, interquartile range, minimum, and maximum) in figure 5A, while scatter values of AKI are shown in figure 5B. Statistical analysis was performed with Kruskal-Wallis test followed by Dunn’s multiple comparison tests (for NGAL), and mixed linear model with adjustment for repeated measures according to the Tukey Kramer procedure (for AKI Score). Statistical significance was accepted at P < 0.05; **P < 0.01 versus RA; ***P < 0.001 versus RA. §§P < 0.01 versus HES; §§§P < 0.001 versus HES. BL1 = Baseline 1, at begin of experiments; BL2 = Baseline 2, following induction of lung injury; BL3 = Baseline 3, after blood drainage and preceding randomization; T4 = 4-h observation period. GEL = gelatin-polysuccinate in RA; HES = hydroxyethyl starch in RA; RA = Ringer’s acetate.