Fig. 6.
Saturation binding analysis of glucocorticoid receptor and mineralocorticoid receptor–specific binding sites with the radiolabeled ligands [3H]corticosterone and [3H]aldosterone in membranes of dorsal root ganglion (DRG) neurons of Freund’s complete adjuvant (FCA)–treated rats compared to controls (Ctrl). (A and B) No significant change in dissociation or affinity konstant (Kd) and maximal specific binding sites (Bmax) of [3H]corticosterone-specific binding sites in dorsal root ganglia of FCA-treated rats versus controls (P > 0.05, two-tailed independent Student’s t test). (C and D) A significant twofold increase in the Bmax of MR-specific [3H]aldosterone binding sites in DRG of FCA-treated rats versus controls (P < 0.05, two-tailed independent Student’s t test). Data are expressed as mean ± SD.