Hypnotic potencies of anesthetic drugs in wild-type (WT) versus β3^-/- zebrafish larvae. Photomotor response probabilities were assessed using video analysis of between 88 and 128 larvae per experiment. Plotted symbols represent mean ± 95% CI (n = 8 to 16 larvae per point; error bars are symmetrical; unidirectional error bars were drawn for clarity). WT is black circles; β3^-/- is red triangles. Lines through data represent logistic fits, colored to match symbols. Results of logistic fits are reported in table 2. Significant differences in fitted EC50s for wild-type versus β3^-/- larvae were found with etomidate (A), propofol (B), pentobarbital (C), and ethanol (I). M, molar; MS-222, tricaine; PMR, photomotor response.