Fig. 1.
Effect of lactic acid concentration on visual attention threshold in the five-choice serial-reaction time task. (A) Lactic acid increased the median cue duration in a concentration-dependent manner after intraperitoneal injection (F[4,50] = 57.2, P < 0.00001). Saline and 0.9% lactic acid did not alter the median cue duration from baseline. *P < 0.05 compared with baseline, saline, and 0.9% lactic acid; #P < 0.05 compared with 1.8% lactic acid. Mean and SD are shown, N = 7 to 13/group. (B) Representative visual cue duration titration curves are shown. Each curve represents an individual session of 100 trials on a given day and treatment.