Fig. 8.
Analgesic mechanism of N-acylphenolamine (AM404) in the spinal cord dorsal horn. AM404 acts on transient receptor potential vanilloid 1 (TRPV1) receptors to depolarize the presynaptic terminals or axons of C-fibers and thus facilitates glutamate release, while inactivated axonal voltage-gated Na+ channels induce conduction blockade of C-fibers. SG = substantia gelatinosa.