Fig. 6.
The effects of single chemokine-C-motif ligand 1 (XCL1)/lymphotactin administration on nociceptive transmission in naive mice. The effects of single intrathecal XCL1 administrations (10 ng, 100 ng, or 500 ng/5 μl) on nociceptive threshold (tail-flick test; A), mechanical allodynia (von Frey test; B), and thermal hyperalgesia (cold plate test; C) were measured at 1, 4, 24, and 96 h after administration. Data are presented as the means ± SD (6 to 10 mice per group). The results were evaluated using one-way ANOVA followed by Bonferroni test for comparisons of selected pairs; *P < 0.05,**P< 0.01, and ***P < 0.001 compared the naive animals versus all groups at respective time points. V = vehicle.