Fig. 2.
Left and right hemisphere motor region-of-interest (ROI) seed-to-voxel whole brain functional connectivity at pre- peripheral nerve block (PNB), during PNB, and after PNB. Random-effects, group-wise independent one-sample Student’s t tests of subject-specific first-level seed-to-voxel connectivity maps by condition. Statistical significance established as peak voxel P <0.001 and multiple-comparison corrected cluster false discovery rate P < 0.05. Whole brain seed-to-voxel intrinsic functional connectivity analyses reflect regions of significant, confound-removed blood oxygen level–dependent (BOLD) time series signal correlation with mean BOLD time series signal within predefined ROIs; in this case, the mean BOLD time series signal within the left and right manual motor regions is shown in figure 1. Colored areas reflect the spatial location of cortical regions with significantly associated time series signal with the left manual motor region seed ROI at pre-PNB (A1), during PNB (A2), and after PNB resolution (post-PNB; A3), while associated cortical regions with shared BOLD time series signal characteristics to the right manual motor region seed ROI are visualized at pre-PNB (B1), PNB (B2), and post-PNB (B3). The red–yellow bar denotes peak voxel statistical significance in t values above the P < 0.001 threshold.